MMR Vaccine (Measles, Mumps and Rubella Vaccine)

Key vaccine facts

This combination vaccine gives protection against three serious diseases: measles, mumps, and rubella. See more information about the safety of combination vaccines.

Before the introduction of the MMR vaccine, all three diseases were extremely common. The majority of people had them at some point, usually as children. Although many people survived without long-term effects, others were left with serious disabilities and some children died. Complications of measles include fatal pneumonia and encephalitis (inflammation of the brain). In the year before a vaccine was introduced, 99 people died from measles complications. Mumps can cause deafness and meningitis, and in the past rubella caused many babies to be born with serious abnormalities.

Between 2001 and 2013 there was a sharp rise in the number of UK measles cases, and three people died (see the Measles page for more information). Numbers of cases fell in 2014 and 2015, but have started to increase again in 2016. In the first half of 2016, 234 measles cases were confirmed - more than four times as many as in the first half of 2015. A significant number of cases have been linked to music festivals and other large public events. Public Health England is advising all young people to check that they are vaccinated against measles before they go to events like these. For more information see the Public Health England news story .

A first dose of the MMR vaccine is given at 12-13 months in the UK schedule. The vaccine is not given earlier than this because studies have shown it does not work well in children under 1 year of age. A booster dose is given at 3 years and 4 months. There is also a catch-up programme for children, teenagers and young adults who have missed out on the MMR vaccine. Anyone who is not sure whether they have had measles, mumps and rubella vaccines can ask their GP for the MMR vaccine.

Single measles, mumps and rubella vaccines are not available in the UK through the NHS. For more information about why this is the case, see the statement from Public Health England .

The MMR vaccine contains live but weakened (attenuated) viruses. It should not be given to people who are clinically immunosuppressed (either due to drug treatment or underlying illness) because the vaccine strains could replicate too much and cause serious infection. This includes babies whose mothers have had immunosuppressive treatment while they were pregnant or breastfeeding. For more information see the MHRA's Drug Safety Update (April 2016) .

There are now a large number of studies that show no evidence at all of any link between the MMR vaccine and autism. In the short film below, experts say why they believe there is no link. See 'Is the vaccine safe?' towards the bottom of this page for a full list of studies.

Ingredients

The vaccine contains live, but weakened (attenuated) strains of the measles, mumps and rubella viruses. These weakened viruses stimulate the immune system but do not cause disease in healthy people

The measles and mumps virus strains are grown on a culture which contains chick embryo cells (see more information about the use of animal cell-lines to grow viruses for vaccines). The viruses are not grown on eggs. This means that there is not enough egg protein in the MMR vaccine to cause allergic reactions, so children with severe egg allergies can safely receive the MMR. In the past, people with an egg allergy were advised not to receive the MMR vaccine, but advice on this changed more than ten years ago. In the short film below, Professor Simon Dobson explains how we know that there is no increased risk of reactions to the MMR vaccine in children who are allergic to eggs.

The rubella virus strain is grown in the laboratory using human cell-lines. See more information on human cell-lines.

There are two MMR vaccines recommended for use in the UK. Both may contain traces of neomycin, an antibiotic used in the production process. See more information on antibiotics in vaccines.

One of the MMR vaccines used in the UK (MMR VaxPro) contains gelatine derived from pigs. The other MMR vaccine used in the UK (Priorix) does not contain gelatine. See more information on gelatine in vaccines.

The vaccine may also contain tiny amounts of products used during the manufacturing process. Click on the links to see more information on our Ingredients page:

The MMR vaccines used in the UK do not contain the preservative thiomersal (mercury).

Side effects

The MMR vaccine is a live attenuated (weakened) vaccine. It should not be given to people who are clinically immunosuppressed (either due to drug treatment or underlying illness) because the vaccine strains could replicate too much and cause a serious infection. This includes babies whose mothers have had immunosuppressive treatment in pregnancy or while breastfeeding. For more information see the MHRA's Drug Safety Update (April 2016) .

The three viruses in the MMR act over different time periods. The following side effects are common but not serious:

  • six to ten days after vaccination: a raised temperature, loss of appetite, and measles-like rash. This can happen when the measles part of the vaccine starts to work, and is normal.
  • More rarely children may get mumps-like symptoms (slightly raised temperature and swollen glands) about three weeks after their immunisation as the mumps part of the vaccine starts to work.
  • The rubella element can cause inflammation in joints (arthritis). Though quite common in adult women, in children this is rare, and usually disappears quickly.

More serious side effects are rare:

  • high temperatures, sometimes leading to fits (also called convulsions or febrile seizures)
  • very rarely, a skin rash of small, bruise-like spots up to six weeks after vaccination (immune thrombocytopenic purpura)

You should consult your doctor if these reactions happen after vaccination. This is mainly to check that it is the vaccine causing the symptoms, and not some unrelated disease.

As with any vaccine, medicine or food, there is a very small chance of a severe allergic reaction (anaphylaxis). Anaphylaxis is different from less severe allergic reactions because it causes life-threatening breathing and/or circulation problems. It is always serious but can be treated with adrenaline. In the UK between 1997 and 2003 there were a total of 130 reports of anaphylaxis following ALL immunisations, but all of these people survived. Around 117 million doses of vaccines were given in the UK during this period, making the overall rate around 1 in 900,000. Depending on the cause of the reaction, and following expert guidance, the person may be able to have vaccinations in the future.

Reactions listed under ‘possible side effects’ or ‘adverse events’ on vaccine product information sheets may not all be directly linked to the vaccine. See Vaccine side effects and adverse reactions for more information on why this is the case.

See more information on the monitoring of vaccine safety.

More information about the vaccine

In the short film below, experts talk about measles and its complications, and the importance of the MMR vaccine.


A life changed by measles: Sarah Clow's story

Sarah Clow fell seriously ill with measles when she was five and was left with lasting disabilities including deafness, partial sight and learning difficulties. Her mother Audrey talks about the impact this has had on Sarah and the whole family. Thanks to Rockhopper TV for the original footage.

Sarah was not vaccinated against measles as a child because she had had eczema. Advice on this has now changed; current advice is that children with eczema can safely receive the MMR vaccine and other vaccines.


SSPE - a serious complication of measles: Sarah Walton's story

Sarah Walton caught measles when she was 11 months old, and at the time recovered well. Twenty four years later, however, she fell ill and was diagnosed with subacute sclerosing panencephalitis (SSPE). SSPE is a persistent viral infection, a rare but devastating complication of measles which leads to a progressive destruction of the central nervous system. It causes dementia, loss of motor control, epilepsy and eventually death. In this video Sarah’s mother Jo talks about the impact that SSPE has had on Sarah and the people around her.

For more information about the egg allergy issues raised in the video, see the 'Ingredients' section above.

Is the vaccine safe?

There are now a large number of studies that show no evidence at all of any link between the MMR vaccine and autism. Autism is a developmental disorder which is usually diagnosed in pre-school children. The original research which suggested a link has now been discredited. The National Autistic Society has issued a statement stating that the weight of evidence points to the fact that ‘there is no statistically significant link between the MMR vaccine and autism’.

Below is a list of studies and their findings. Click on the links to view the abstracts (summaries) of the scientific papers:

Page last updated: 
Monday, August 15, 2016

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